Course Title:
BIOFLUID MECHANINCS
Code:
BME-A15
Semester: 2nd
Weekly teaching hours CREDITS (ECTS)
Lecture: 2 5

### SYLLABUS

Fundamentals of Fluid Mechanics

Intrinsic Fluid Properties, Hydrostatics

Macroscopic Balances of Mass and Momentum, Microscopic Balances of Mass and Momentum, Bernoulli Equation

Dimensional Analysis. Fluid Mechanics in a Straight Tube, Boundary Layer Separation

Introduction to Mechanics of Materials. Linear elastic solid and linear viscous fluid.

Viscoelasticity, elastic moduli, viscosity.

Analysis of Thin-Walled Cylindrical Tubes. Analysis of Thick-Walled Cylindrical Tubes

Heart. Cardiac Valves, Systemic Circulation, Coronary Circulation

Pulmonary Circulation and Gas Exchange in the Lungs, Cerebral and Renal Circulations

Microcirculation. Regulation of the Circulation. Atherosclerosis

Rheology of Blood and Vascular Mechanics

Rheology of Blood. Linear flux of blood, Casson equation, Rauleaux formation condition.

Hydrostatics in the Circulation, Applications of the Bernoulli Equation

Rigid Tube Flow Models

Estimation of Entrance Length and Its Effect on Flow Development in Arteries

Flow in Collapsible Vessels

Unsteady Flow and Nonuniform Geometric Models

Windkessel Models for the Human Circulation

Continuum Models for Pulsatile Flow Dynamics, Hemodynamic Theories of Atherogenesis

Wall Shear Stress and Its Effect on Endothelial Cells

Flow through Curved Arteries and Bifurcations, Flow through Arterial Stenoses and Aneurysms

Native Heart Valves. Aortic and Pulmonary Valves, Mitral and Tricuspid Valves

Prosthetic Heart Valve Dynamics

Brief History of Heart Valve Prostheses, Hemodynamic Assessment of Prosthetic Heart Valves

In Vitro Studies of Coagulation Potential and Blood Damage

Durability of Prosthetic Heart Valves, Current Trends in Valve Design

Vascular Therapeutic Techniques

### Learning outcomes

Upon completion of the course, students will:

• Possess an advanced understanding of fluid and solid mechanics as applied to the analysis of blood flow and other physiological flows.
• Apply advanced principles of fluid dynamics, hydrostatics, and mass and momentum balances to analyze complex fluid behavior in biological systems.
• Utilize dimensional analysis to characterize and predict fluid flow in various physiological contexts.
• Demonstrate proficiency in analyzing the mechanics of materials, including linear elastic solids, linear viscous fluids, and viscoelasticity.
• Analyze the behavior of cylindrical tubes, with a focus on their role in cardiovascular circulation and microcirculation.
• Evaluate the regulation of circulation, atherosclerosis, and rheology of blood and vascular mechanics.
• Apply advanced hemodynamic theories to understand fluid flow in curved arteries, bifurcations, stenoses, aneurysms, and heart valves.
• Assess prosthetic heart valves, including their dynamics, hemodynamics, and durability

### General Competences

Critical Thinking: Analyze and evaluate complex fluid mechanics concepts in the context of biofluid dynamics.

Problem-Solving: Address challenges in blood flow analysis and physiological fluid dynamics using appropriate mathematical and computational techniques.

Quantitative and Analytical Skills: Apply advanced mathematical and statistical methods to analyze fluid behavior and interpret experimental data.

Scientific Inquiry: Formulate research questions, design experiments, and contribute to knowledge advancement in biofluid mechanics